Pharmaceutical compounds.



' all whom it mag concern:

1X12}; is'a specification;

barren saunas ra'rnnir anion.

iKZ'El'JHELZJI HIEMENZ AND "WALTER KROPP, OF ELBERFELD, GERMANY, ASSIGN R5 TO EEtItBENFABlRlKEN VORNLIRIEDB. BAYER & OF ELBERFELD, GERMANY, A

Ctbkz-EFQRATIUN or GERMANY.

PHARMACEUTICAL coiurounns.

as Drawing.

Be it knownthat we, lVILI-IELM and ill/trans Ksorr, doctors of philosophy, chemists citizens oi? the German Empire; residing at Elberfeld, Germany, have invented new and useful Improvements in New Pharmaceutical Gompounds, of which the follow- We have found that the hitherto unknown derivatives; of iodocinnarnic acid of the formula:

pounds consists tor instance in treating the chloride of the iodocinnaniic acids, such asof diiodocinnamic acid, beta-lodocinnamic acirh etc, with ammonia or amins.

@ur new preparations are crystallizable compounds. They are insoluble in water and are decomposed by treatment with a hot alcoholic solution of caustic pot-ash.

In, orderv to illustrate the new invention, we can proceed as follows, the parts being by weight I Example 1": 400 parts of diiodoclnnamic acid are slowly added to an. emulsion of 208 parts of finely powdered P61 in chloroform. "ii' hen the-evolution of HCl ceases chloroform and l QCl are distilled ed and the chlorid of the diiodocinnamic acid is introduced into an aqueous solution of ammonia which is stirred. The precipitate is filtered Specification of Letters Patent.

Hrnnnnz otl and washed with water; alcohol and ether. It crystallizes'from glacial acetic acid. On

being heated to 200 it is decomposed.-

Example 2: In order to produce the ureid of the diiodocinnamic acid the chlorid of this acid is heated with 2% molecules of urea on the water bath. The mass thus obtained is boiled with water and then with alcohol.

The ureid melts a't 185*186 C. cultly soluble in most solvents. We claim It is difii- LAs new products acid amids of'iodocinn'amic acids, which products are practi 'cally insoluble in water and decomposed by treatment with a hot alcoholic potash solution, substantially as described.

2.. As new products acld amids of dl-iodo- 'cinnamic acid, which products are practically insoluble in water, and are decomposed by treatment with a hot alcoholic potash solution, substantially as described.

'3. As new amide of iodo-cinnamic acids of theformula ANH .where A is the acidyl radical of the acid amid, which bodies are practically insoluble in water, and are decomposed by treatment with ahot alcoholic potash solution, substantially as described.

4:. The herein described amid of the diiodocinnamic acid of the formula:

rincizcroonn products the unsubstituted acid I Patented Mar. 18,1913. Application filed June 10, 1911. Serial No. 632,424.. 

